Designing of hydroxyapatite-gelatin based porous matrix as bone substitute: Correlation with biocompatibility aspects
نویسندگان
چکیده
منابع مشابه
Fabrication of Porous Hydroxyapatite-Gelatin Scaffolds Crosslinked by Glutaraldehyde for Bone Tissue Engineering
In this study, to mimic the mineral and organic components of natural bone, hydroxyapatite[HA] and gelatin[GEL] composite scaffolds were prepared using the solvent-casting method combined with a freeze drying process. Glutaraldehyde[GA] was used as a cross linking agent and sodium bisulfite was used as an excess GA discharger. Using this technique, it is possible to produce scaffolds with mecha...
متن کاملFabrication of Porous Hydroxyapatite-Gelatin Composite Scaffolds for Bone Tissue Engineering
Background: engineering new bone tissue with cells and a synthetic extracellular matrix represents a new approach for the regeneration of mineralized tissues compared with the transplantation of bone (autografts or allografts). Methods: in this study, to mimic the mineral and organic component of natural bone, hydroxapatite (HA) and gelatin (GEL) composite scaffolds were prepared. The raw mater...
متن کاملFabrication of Porous Hydroxyapatite Scaffolds as Artificial Bone Preform and its Biocompatibility Evaluation
In this study, a novel porous hydroxyapatite scaffold was designed and fabricated to imitate natural bone through a multipass extrusion process. The conceptual design manifested unidirectional microchannels at the exterior part of the scaffold to facilitate rapid biomineralization and a central canal that houses the bone marrow. External and internal fissures were minimized during microwave sin...
متن کاملPorous block hydroxyapatite as a bone graft substitute in the correction of jaw and craniofacial deformities
Modulation of the immune system as an approach to attack cancer has been explored for the past 50 years. Efficacy of this treatment has been achieved in a limited number of patients. However, a major obstacle of immune therapy is the toxicity related to the nonspecific nature of immune activation. Efforts to improve the specificity of the immune response have been investigated through the use o...
متن کاملNovel unidirectional porous hydroxyapatite used as a bone substitute for open wedge high tibial osteotomy
PURPOSE The purpose of this study was to clinically and radiologically evaluate the availability, osteoconductivity, and resorption of a novel unidirectional porous hydroxyapatite (UDPHAp) used as an artificial substitute for open wedge high tibial osteotomy (OWHTO). Our hypothesis was that UDPHAp is a safe and useful bone substitute for OWHTO. MATERIALS AND METHODS Seven patients (2 men and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Express Polymer Letters
سال: 2008
ISSN: 1788-618X
DOI: 10.3144/expresspolymlett.2008.25